The research work conducted by ELI relies on a network of European-wide exchanges, collaboration and coordination.
Several times a year, ELI organises workshops with 20 to 50 European specialists focusing on a precise topic. Together, they analyse the issue to be resolved and set a tailored action plan. The work to be conducted is then either divided up between the different academic groups or handled jointly.
The therapeutic solutions proposed have been tested through international clinical trials coordinated by several groups within dedicated operational structures.
This system, based on a sharing of expertise, will help speed up progress on lymphoma and set standards for quality treatment at the international level.
The Aristotle Study
was initiated by Massimo Federico after the 3rd Workshop in Madrid.
Histological transformation (HT) of FL to aggressive lymphoma is a particularly serious event with a significant impact on patient outcome. The aim of the Aristotle study was to assess the risk of HT and its outcome in the immune-chemotherapy era.
Eleven cooperative groups or institutions contributed to this study, providing information on 10,001 FL cases, 8,116 of them assessable for analysis. These patients had a histological confirmed FL grade 1, 2, or 3a, diagnosed between 1997 and 2013. HT was defined as a biopsy-proven aggressive lymphoma that occurred as a first event after front-line therapy.